目 录
第一章 研究背景...............................................................................................1
1.1 产业界定...............................................................................................1
1.1.1 国内外对生物医药产业的界定 .......................................................1
1.1.2 本报告所涉内容的界定 ...................................................................1
1.2 分类体系...............................................................................................1
1.2.1 化学药 ...............................................................................................1
1.2.2 中药 ...................................................................................................3
1.2.3 生物技术药物 ...................................................................................3
第二章 总体态势.............................................................................................11
2.1 生物医药发展脉络.............................................................................11
2.1.1 新药研发发展历程 .........................................................................11
2.1.2 药物靶点研究的发展历程 .............................................................21
2.1.3 药物产品开发的发展历程 .............................................................28
2.1.4 临床研究的发展历程 .....................................................................35
2.2 国际形势判断.....................................................................................37
2.2.1 总体判断 .........................................................................................37
2.2.2 产品类型判断 .................................................................................53
2.2.3 发展模式判断 .................................................................................55
2.2.4 主要国家和地区判断 .....................................................................57
2.3 国内形势判断.....................................................................................60
2.3.1 总体判断 .........................................................................................60
2.3.2 发展环境 .........................................................................................67
2.3.3 市场需求 .........................................................................................73
2.3.4 技术态势 .........................................................................................83
2.3.5 企业竞争 .........................................................................................84
第三章 产品领域.............................................................................................88
3.1 化学药.................................................................................................88
3.1.1 创新药物 .........................................................................................88
3.1.2 通用名药 .........................................................................................92
3.1.3 化学原料药 .....................................................................................94
3.1.4 化学药制剂 .....................................................................................98
3.2 生物技术药物...................................................................................101
3.2.1 抗体药物 .......................................................................................104
3.2.2 疫苗 ...............................................................................................122
3.2.3 基因工程药物 ...............................................................................125
3.2.4 血液制品 .......................................................................................126
3.2.5 诊断试剂 .......................................................................................127
3.2.6 生物仿制药 ...................................................................................128
3.3 中药...................................................................................................130
3.3.1 中药行业整体情况 .......................................................................130
3.3.2 中药配方颗粒概况 .......................................................................136
3.3.3 国内中药配方颗粒市场处于快速成长期 ...................................139
3.3.4 主要配方颗粒生产企业 ...............................................................141
3.3.5 未来市场前景分析 .......................................................................143
3.3.6 投资标的与投资建议 ...................................................................145
第四章 技术分析...........................................................................................146
4.1 药物靶标筛选技术...........................................................................146
4.1.1 技术成熟度 ...................................................................................146
4.1.2 国内外差距 ...................................................................................147
4.2 先导化合物的发现...........................................................................148
4.2.1 技术成熟度 ...................................................................................148
4.2.2 国内外差距 ...................................................................................153
4.3 先导化合物优化方法.......................................................................154
4.3.1 技术成熟度 ...................................................................................154
4.3.2 国内外差距 ...................................................................................155
4.4 哺乳动物细胞表达技术...................................................................156
2目 录
第一章 研究背景...............................................................................................1
1.1 产业界定...............................................................................................1
1.1.1 国内外对生物医药产业的界定 .......................................................1
1.1.2 本报告所涉内容的界定 ...................................................................1
1.2 分类体系...............................................................................................1
1.2.1 化学药 ...............................................................................................1
1.2.2 中药 ...................................................................................................3
1.2.3 生物技术药物 ...................................................................................3
第二章 总体态势.............................................................................................11
2.1 生物医药发展脉络.............................................................................11
2.1.1 新药研发发展历程 .........................................................................11
2.1.2 药物靶点研究的发展历程 .............................................................21
2.1.3 药物产品开发的发展历程 .............................................................28
2.1.4 临床研究的发展历程 .....................................................................35
2.2 国际形势判断.....................................................................................37
2.2.1 总体判断 .........................................................................................37
2.2.2 产品类型判断 .................................................................................53
2.2.3 发展模式判断 .................................................................................55
2.2.4 主要国家和地区判断 .....................................................................57
2.3 国内形势判断.....................................................................................60
2.3.1 总体判断 .........................................................................................60
2.3.2 发展环境 .........................................................................................67
2.3.3 市场需求 .........................................................................................73
2.3.4 技术态势 .........................................................................................83
2.3.5 企业竞争 .........................................................................................84
第三章 产品领域.............................................................................................88
3.1 化学药.................................................................................................88
4.4.1 技术成熟度 ...................................................................................156
4.4.2 国内外差距 ...................................................................................159
4.5 生产原料、设备和生产介质...........................................................160
4.5.1 技术成熟度 ...................................................................................160
4.5.2 国内外差距 ...................................................................................160
4.6 人源化及全人抗体的构建及优化技术...........................................162
4.6.1 技术成熟度 ...................................................................................162
4.6.2 国内外差距 ...................................................................................165
4.7 单克隆抗体纯化技术.......................................................................166
4.7.1 技术成熟度 ...................................................................................166
4.7.2 国内外差距 ...................................................................................167
第五章 发展主体...........................................................................................168
5.1 区域分布...........................................................................................168
5.1.1 产业基地 .......................................................................................168
5.1.2 区域分析 .......................................................................................178
5.2 医药企业...........................................................................................207
5.2.1 上市企业 .......................................................................................207
5.2.2 中小企业 .......................................................................................220
第六章 基本结论...........................................................................................222
6.1 全球生物医药产业机遇与挑战并存...............................................222
6.2 国内生物医药产业面临新的形势...................................................223
