倪子富，王乐’
(河南工业大学生物工程学院，郑州450001)
摘要:木糖醇作为食品，医药，化工等领域的重要合成原料，具有极高的应用价值。利用微生物法发酵生
产木糖醇具有原料来源广泛，发酵条件温和，产物分离纯化简单等优势，一直被认为是绿色经济的木糖醇生
产工艺路线。本文通过对生物法生产木糖醇的热点问题发酵菌种的分类和发酵性能、基因工程菌的改造策
略、以半纤维素水解液为发酵底物的制取、脱毒处理和发酵条件优化以及在固定化技术中所应用到的载体
和固定化方法等几个方面进行梳理和归纳，系统阐述了生物法发酵生产木糖醇的最新研究进展，并对其前
景进行了展望。
关键词:木糖醇 菌株 发酵调控 固定化
Research advances in xylitol production by biological fermentation
NI Zi-Fu, WANG Le*
(College of Biological Engineering, Henan University of Technology, Zhengzhou 450001, China
ABSTRACT: Xylitol, as the important synthetic materials in food, medicine, chemical industry and other fields, has
a high application value. The microbial methods of xylitol production have some obvious advantages, such as the
wide raw material sources, moderate fermentation condition, simple and convenient way to separation. Therefore, it
has been regarded as a green economy route of xylitol production. This paper aimed to summarize some aspects of
biological fermentation in xylitol production. It included the classification and performance of fermentation strains,
the transformation strategy of genetic engineering bacteria, the preparation and detoxification of hemicellulose
hydrolysate, the optimization of fermentation from饰drolysate, and the carrier and methods of immobilization
technology. The advanced researches of biological methods for xylitol production were elaborated. Afterwards, its
prospect was outlooked
KEY WORDS: xylitol; strain; fermentation control; immobilization
