Anti-ADAM17 monoclonal antibody (DCABY-4144)

Host Species

Mouse

Antibody Isotype

IgG1

Clone

222709

Species Reactivity

Human

Immunogen

Insect ovarian cell line T. ni-derived recombinant human TACE/ADAM17. Pro18-Asn671 (predicted) Accession Number P78536

Conjugate

Unconjugated

Application Notes

ELISA Capture: 2-8 μg/mL; ELISA Detection: 0.5-2.0 μg/mL
We recommend the following for sandwich ELISA (Capture - Detection):
DCABY-4144 - DCABY-4328

*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Alternative Names

ADAM17; ADAM metallopeptidase domain 17; CSVP; TACE; NISBD; ADAM18; CD156B; disintegrin and metalloproteinase domain-containing protein 17; TNF-alpha convertase; snake venom-like protease; TNF-alpha converting enzyme; ADAM metallopeptidase domain 18; tumo

Entrez Gene ID

6868

UniProt ID

B2RNB2

Feldinger, K; Generali, D; et al. ADAM10 mediates trastuzumab resistance and is correlated with survival in HER2 positive breast cancer. ONCOTARGET 5:6633-6646(2014).

Yu, CC; Tsai, LL; et al. miR145 Targets the SOX9/ADAM17 Axis to Inhibit Tumor-Initiating Cells and IL-6-Mediated Paracrine Effects in Head and Neck Cancer. CANCER RESEARCH 73:3425-3440(2013).