烟曲霉素(fumagillin )别称夫马菌素

 

 

　　黄色针状结晶。熔点194～195℃。旋光度[α]D25-26.6°(c=1,乙醇)。几乎不溶于水、稀酸类、饱和烃，溶于乙醇等有机溶剂。既具抗生素活性，又有致癌作用。
   
     中文名烟曲霉素

英文名Fumagillin
别    称夫马吉林; 夫马菌素; 抗虫痢
化学式C26H34O7
分子量458.54
CAS登录号23110-15-8
EINECS登录号245-433-8
熔    点194--195℃
沸    点608.8°Cat760mmHg
水溶性不溶
密    度1.19g/cm3
外    观淡黄色固体
闪    点198.8°C
应    用抗寄生虫治疗
安全性描述S36
危险性符号6.1
危险性描述20/22

 

Fumagillin is a complex biomolecule and used as an antimicrobial agent. It was isolated in 1949 from the microbial organism Aspergillus fumigatus.

 

In animals

 

 

It was originally used against microsporidial parasites Nosema apis and Nosema ceranae infections in honey bees.

 

Some studies found it to be effective against some myxozoan parasites, including Myxobolus cerebralis, an important parasite of fish; however, in the more rigorous tests required for U.S. Food and Drug Administration approval, it was ineffective.

 

There are reports that fumagillin controls Nosema ceranae, which has recently been hypothesized as a possible cause of colony collapse disorder.

 

Fumagillin is also investigated as an inhibitor of malaria parasite growth.

 

In humans

 

 

Fumagillin has been used in the treatment of microsporidiosis. It is also an amebicide.

 

Fumagillin can block blood vessel formation by binding to an enzyme called methionine aminopeptidase 2. and for this reason, the compound, together with semisynthetic derivatives, are investigated as a angiogenesis inhibitor in the treatment of cancer.

 

Preliminary clinical trials are being conducted by Zafgen into using the fumagillin analog beloranib for weight loss.

 

Fumagillin and the related fumagillol (the hydrolysis product) have been a target in total synthesis, with several reported successful strategies, racemic, asymmetric and formal.